Ohana was born in Casablanca on June 12th, 1913. He originally studied architecture, but abandoned this in favour of a musical career, initially as a pianist. He studied under Alfredo Casella in Rome, returning to France in 1946. Around this time he founded the "Groupe Zodiaque", which fought against prevailing musical dogma. His mature musical style shows the influence of Mediterranean folk music, particularly the Andalusian cante jondo.
Ohana's output includes the choral works Office des Oracles and Avoaha (1992), three string quartets (1963, 1980, 1989), and two suites for ten-string guitar: Si le jour paraît... (1963) and Cadran lunaire (1981-2), as well as a Tiento for six-string guitar (1957). He also wrote operas entitled Syllabaire pour Phèdre and La Celestina.
He is also known for his extensive use of microtonality - for example, third-and quarter-tones in pieces like Le Tombeau de Debussy and Si le jour paraît... He was influenced by the use of microintervals in the cante jondo.
Ohana rarely composed for large symphony orchestra: Synaxis (1966), Livre des Prodiges (1979) and T'Harân-Ngô (1973-1974). He composed two cello concertos, one piano concerto and a guitar concerto (1950-58, dedicated to Narciso Yepes).
Maurice Ohana was awarded the first prize of the "contemporary music composer of the year" at the first "Victoires de la Musique Classique" in 1994.
Maurice Ohana died in Paris on November 13th, 1992.